Titration with Oxymorphone Extended Release to Achieve Effective Long-Term Pain Relief and Improve Tolerability in Opioid-Naive Patients with Moderate to Severe Pain
نویسندگان
چکیده
منابع مشابه
Safe IV opioid titration in patients with severe acute pain.
PROVIDING EFFECTIVE PAIN control while minimizing opioid-induced adverse effects in patients with severe acute pain presents special challenges for clinicians who work in PACUs, outpatient surgery settings, emergency departments (EDs), and intensive care units (ICUs) because they must also deal with the additional central nervous system depression caused by the sedative and anesthetic agents th...
متن کاملPain relief and tolerability balance of immediate release tapentadol or oxycodone treatment for patients with moderate to severe osteoarthritis or low back pain.
PURPOSE Opioid treatment effectiveness may be best compared using definitions of treatment response, which combine measures assessing pain reduction and the occurrence of adverse events (AEs). This analysis of data from two phase III clinical trials was conducted to examine the pain relief and tolerability (PRT) balance of immediate release (IR) tapentadol and oxycodone in patients with moderat...
متن کاملTreatment with prolonged-release oxycodone/naloxone improves pain relief and opioid-induced constipation compared with prolonged-release oxycodone in patients with chronic severe pain and laxative-refractory constipation.
PURPOSE Laxative-refractory opioid-induced constipation (OIC) is defined as OIC despite using 2 laxatives with a different mechanism of action (based on the Anatomical Therapeutic Chemical Classification System level 4 term [contact laxatives, osmotically acting laxatives, softeners/emollients, enemas, and others]). OIC has a significant impact on the treatment and quality of life of patients w...
متن کاملEffectiveness and gastrointestinal tolerability during conversion and titration with once-daily OROS® hydromorphone extended release in opioid-tolerant patients with chronic low back pain
PURPOSE To describe the efficacy and safety of hydromorphone extended-release tablets (OROS hydromorphone ER) during dose conversion and titration. PATIENTS AND METHODS A total of 459 opioid-tolerant adults with chronic moderate to severe low back pain participated in an open-label, 2- to 4-week conversion/titration phase of a double-blind, placebo-controlled, randomized withdrawal trial, con...
متن کاملUsing opioids for patients with moderate to severe pain.
In the United States, many visits to physician offices are for complaints of pain. Patients who have moderate to severe pain can be effectively treated with different modalities, including opioids. Proper management requires that physicians be open-minded and thorough. Physicians should take a complete history and perform a complete physical evaluation including an osteopathic structural examin...
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ژورنال
عنوان ژورنال: Pain Medicine
سال: 2008
ISSN: 1526-2375,1526-4637
DOI: 10.1111/j.1526-4637.2007.00390.x